Table 2.
1 year Overall Survival | p-value | Day +100 CMV-free survival | p-value | Day +100 CMV-free, steroid-free, GF-free survival | p-value | |
---|---|---|---|---|---|---|
D/R Serostatus | NS | <0.0001 | <0.0001 | |||
−/− | 86% (77–92%) | 93% (85–97%) | 51% (40–61%) | |||
−/+ | 76% (64–85%) | 39% (28–51%) | 27% (17–38%) | |||
+/− | 84% (65–93%) | 84% (66–93%) | 55% (36–70%) | |||
+/+ | 78% (71–84%) | 41% (33–49%) | 25% (19–32%) | |||
Graft Source | NS | 0.01 | 0.08 | |||
Marrow | 83% (72–90%) | 55% (42–66%) | 35% (24–46%) | |||
PBSC | 79% (74–84%) | 62% (56–67%) | 37% (31–43%) | |||
UCB | 84% (63–94%) | 40% (21–58%) | 20% (7–37%) | |||
T-cell Manipulation | NS | 0.08 | NS | |||
PTCy-based | 84% (72–91%) | 57% (43–69%) | 39% (27–52%) | |||
Serotherapy | 91% (83–96%) | 67% (56–76%) | 41% (31–52%) | |||
TCD | 87% (73–94%) | 60% (44–73%) | 29% (17–42%) | |||
CNI/mTORi-based | 78% (70–84%) | 58% (44–65%) | 35% (28–43%) |
Abbreviations: CMV, cytomegalovirus; GF, graft failure; D/R, donor/recipient; PBSC, peripheral blood stem cell; UCB, umbilical cord blood; PTCy, post-transplantation cyclophosphamide; TCD, ex vivo T-cell depletion; CNI, calcineurin inhibitor; mTORi, mammalian target of rapamycin inhibitor