Table 2.

Genes, their biological function and the expression ratio of genes in acute graft-host-disease to those in lupus erythematosus

Gene	Full name	Biological function	Ratio (GVHD/LE)	P*
MX1†	MX dynamin-like GTPase 1	Metabolism of GTP; antiviral	0.53	< 0.001*
OAS3†	2’-5’-oligoadenylate synthetase 3	Cellular protein synthesis inhibition; antiviral	0.58	< 0.001*
TAP1†	Transporter 1, ATP binding cassette subfamily B member	Transport of degraded cytosolic peptides within the endoplasmic reticulum to allow assembly of class 1 molecules	0.28	< 0.001*
STAT3†	Signal transducer and activator of transcription 3	Transcription activation	0.67	0.001*
GBP2	Guanylate-binding protein 2	IFN-γ-induced GTPase	1.00	0.91
THBS2	Thrombospondin	Cellular adhesion and migration; suppresses IFN-γ and TNF-α	0.74	< 0.001*
SQRDL	Sulfide quinone reductase	Decreasing toxic levels of sulphide	0.73	< 0.001*
PTK2	Protein tyrosine kinase 2	Cell surface adhesion, signalling	0.42	< 0.001*
PSMA3	Proteasome subunit alpha 3	Processing of class 1 MHC peptides	0.71	< 0.001*
LOXL1	Lysyl oxidase-like 1	Synthesis of connective tissue, including collagen and elastin	0.57	< 0.001*
ITGA5	Integrin subunit alpha 5	Cell surface adhesion, signalling	0.85	< 0.001*
HYOU1	Hypoxia upregulated protein 1	Protects against hypoxia-induced apoptosis	0.53	< 0.001*
LAMB1	Laminin subunit beta 1	Cellular attachment, chemotaxis	0.24	< 0.01*
IVL	Involucrin	Formation of cell envelope	1.20	< 0.01*

GVHD, graft-versus-host disease; IFN, interferon; LE, lupus erythematosus; MHC, major histocompatibility complex. TNF, tumour necrosis factor. Genes were assessed by quantitative reverse transcription PCR from formalin-fixed, paraffin-embedded skin biopsy specimens.

^*Statistical significance was set at P < 0.05

^†known to be induced by type I interferons.