Table 3.
Top-performing logistical regression models developed to differentiate acute graft-versus-host disease and lupus erythematosus of the skin. Models are based on quantitative expression of the genes listed, as determined by quantitative RT-PCR from formalin-fixed, paraffin-embedded skin biopsy specimens. AUC, area under the curve.
| Gene | Estimate | P* | AUC |
|---|---|---|---|
| Model 1 | |||
| TAP1 | −0.4 | < 0.01* | 1 |
| LOXL1 | −3.85 | < 0.001* | |
| ITAG5 | −1.43 | 0.25 | |
| Intercept | 44.075 | ||
| Model 2 | |||
| TAP1 | −2.049 | 0.04 | 1 |
| LOXL1 | −9.703 | < 0.001* | |
| OAS2 | −1.435 | 0.14 | |
| Intercept | 107.318 | ||
| Model 3 | |||
| TAP1 | −1.902 | < 0.001* | 1 |
| LOXL1 | −9.926 | < 0.001* | |
| Intercept | 95.153 |
*
Statistical significance was set at P < 0.05.