Table 3. HRs and 95% CIs of the incidence of BTC and IHBDC according to alcohol consumption in men.

	Cases	IR per 100,000	HRa	95% CI
				Lower	Upper
IHBDC
Non drinker	13	7.2	1.00
Occasional drinker	7	9.1	1.57	0.62	3.98
Regular drinker (<300 g of ethanol)	32	8.8	1.51	0.78	2.89
Regular drinker (≥300 g of ethanol)	26	12.5	1.96	0.99	3.91
P-trend				0.065
BTC
Non drinker	61	33.7	1.00
Occasional drinker	17	22.1	0.92	0.53	1.59
Regular drinker (<300 g of ethanol)	101	27.8	1.08	0.78	1.49
Regular drinker (≥300 g of ethanol)	57	27.4	1.04	0.71	1.52
P-trend				0.702
Subtypes of BTC
GBC
Non drinker	19	10.5	1.00
Occasional drinker	6	7.8	1.01	0.40	2.57
Regular drinker (<300 g of ethanol)	30	8.3	0.93	0.52	1.67
Regular drinker (≥300 g of ethanol)	12	5.8	0.71	0.34	1.51
P-trend				0.430
EHBDC
Non drinker	35	19.3	1.00
Occasional drinker	7	9.1	0.72	0.32	1.63
Regular drinker (<300 g of ethanol)	53	14.6	1.05	0.68	1.63
Regular drinker (≥300 g of ethanol)	38	18.3	1.23	0.76	1.99
P-trend				0.362
AVC
Non drinker	7	3.9
Occasional drinker	3	3.9	1.14	0.29	4.52
Regular drinker (<300 g of ethanol)	12	3.3	1.01	0.39	2.58
Regular drinker (≥300 g of ethanol)	4	1.9	0.56	0.16	1.99
P-trend				0.462

AVC, ampulla of Vater cancer; CI, confidence interval; BTC, biliary tract cancer; EHBDC, extrahepatic bile duct cancer; GBC, gallbladder cancer; HR, hazard ratio; IHBDC, intrahepatic bile duct cancer; IR, incidence ratio.

^aAdjusted for age, study area, body mass index, history of cholelithiasis, history of diabetes mellitus, history of chronic hepatitis or cirrhosis, Japanese tea consumption, and smoking.