Table 5.
Logistic regression odds-ratios for co-presence of ICD10-code for circulatory; respiratory; digestive disease at 941 eligible opioid-related DRDs; and for co-presence of Y-code (undetermined intent). Interaction tested: aged 45+ years at opioid-DRD and quantity of methadone from deceased’s latest CHI-identified prescription in the year prior to opioid-DRD in top quintile.
| Covariate | Odds Ratio coefficients (95% confidence interval)** |
||||
|---|---|---|---|---|---|
| Circulatory 83 co-present (without/with interaction) |
Respiratory 109 co-present |
Digestive 52 co-present |
Y-code 135 co-present |
||
| Risk-constant relates to baseline individual (methadone-specific DRD, aged < 35 years at death, middle three quintiles of latest methadone prescription in the year prior to death) | |||||
| Risk-constant | 0.05 (0.02 to 0.10) |
0.06 (0.03 to 0.12) |
0.06 (0.03 to 0.11) |
0.05 (0.02 to 0.12) |
0.29 (0.19 to 0.43) |
| Opioid specificity of 941 opioid-related DRDs (baseline: 498 methadone-specific DRDs) | |||||
| 176 Heroin-specific DRDs | 0.53 (0.37 to 0.76) |
0.50 (0.24 to 1.06) |
0.66 (0.32 to 1.33) |
0.13 (0.03 to 0.54) |
0.50 (0.28 to 0.88) |
| 267 Heroin and methadone-DRD | 0.44 (0.24 to 0.82) |
0.43 (0.23 to 0.81) |
1.01 (0.63 to 1.62) |
0.16 (0.06 to 0.44) |
0.39 (0.24 to 0.64) |
| Age-group at opioid-related DRD (baseline: under 35 years of age at death) | |||||
| 35-44 years | 1.86 (0.90 to 3.84) |
1.92 (0.93 to 3.96) |
1.90 (0.97 to 3.69) |
1.73 (0.16 to 19.3) |
0.84 (0.54 to 1.29) |
| 45-54 years | 3.39 (1.61 to 7.13) |
2.44 (1.11 to 5.33) |
4.76 (2.44 to 9.27) |
2.14 (0.87 to 5.27) |
0.54 (0.32 to 0.91) |
| 55+ years | 11.59 (4.10 to 32.7) |
8.50 (2.89 to 25.0) |
15.80 (5.93 to 42.1) |
4.62 (1.22 to 17.5) |
0.52 (0.15 to 1.87) |
| Quintile for quantity of methadone prescribed based on latest CHI-indexed prescription in the year prior to opioid-related DRD (baseline: 557 in middle three quintiles, 245 to 1889 mg) | |||||
| Bottom: < 245 mg (n = 196) |
1.55 (0.86 to 2.80) |
1.51 (0.84 to 2.71) |
0.79 (0.43 to 1.44) |
1.30 (0.58 to 2.90) |
0.64 (0.36 to 1.14) |
| Top: > 1890 mg (n = 188) |
1.22 (0.68 to 2.20) |
0.51 (0.19 to 1.36) |
1.14 (0.68 to 1.90) |
1.28 (0.66 to 2.50) |
1.58 (1.03 to 1.46) |
| Interaction: top quintile for quantity of methadone prescribed and aged 45+ years at opioid-related DRD | |||||
| Top quintile * 45+ years at opioid-DRD | 4.90 (1.45 to 16.5) |
||||
| p-value for INTERACTION | P ˜ 0.011 | P ˜ 0.30 | P ˜ 0.36 | P ˜ 0.31 | |
| Regression chi-square (df) with/without INTERACTION |
46.35 (8 df) 39.20 (7 df) |
56.62 (8 df) 55.56 (7 df) |
39.05 (8 df) 38.19 (7 df) |
35.45 (8df) (7df) |
|
Boldface: for covariate headings. **Please see APPENDIX1 for the corresponding Odds Ratios for 1175 opioid-related deaths in which quintile relates to the quantity of methadone prescribed according to the deceased’s latest CHI-identified methadone-prescription.