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Study design flow-chart. Abbreviation: CVID_QoL, common variable immunodeficiency quality of life questionnaire; fSCIG, facilitated subcutaneous immunoglobulin; GHQ-12 GHQ-12, questionnaire; IVIG, intravenously-administered immunoglobulins; IVIG + SCIG, immunoglobulin replacement therapy by combined intravenous and subcutaneous route of administration; IgRT, immunoglobulin replacement treatment; SCIG, subcutaneous Immunoglobulins
