Fig. 3.

GHQ status and CVID_QoL score. Proportion of GHQ-12-positive participants and global. EF, RF, and GSS scores (panel a) recorded for CVID grouped according to the route of IgG replacement treatment. CVID_QoL global. EF, RF, and GSS are expressed as percentage of the respective total score with higher values indicating increasing disability. Scores of eight single items of the CVID_QoL related to the immunoglobulin treatment (panel b). p values by the t test. **p ≤ 0.01. Abbreviation: CVID_QoL, common variable immunodeficiency quality of life questionnaire; EF, emotional functioning; IVIG, intravenously administered immunoglobulins; fSCIG, facilitated subcutaneous immunoglobulin; GHQ-12, GHQ-12 questionnaire; GSS, gastrointestinal and skin symptoms; IgRT, immunoglobulin replacement treatment; IVIG + SCIG, immunoglobulin replacement therapy by combined intravenous and subcutaneous route of administration; Q, question; RF, relational functioning; SCIG, subcutaneous immunoglobulins