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. 2019 Mar 15;79(5):555–562. doi: 10.1007/s40265-019-01095-z
A liposomal formulation of amikacin, administered once daily via inhalation following nebulization
Designed to facilitate targeted and localized drug delivery to the lungs while minimizing systemic exposure
As an add-on to guidelines-based therapy (GBT), ALIS significantly increases the odds of achieving sputum culture conversion compared with GBT alone
Acceptable tolerability; carries a black box warning pertaining to a risk of increased respiratory adverse events (leading to hospitalizations in some cases)