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. 2019 Mar 27;10:303. doi: 10.3389/fphar.2019.00303

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Copyright © 2019 Alshaker, Wang, Brewer and Pchejetski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene-set enrichment analysis of gene ontology biological process enrichment pathways. Human prostate cancer cells lines PC-3 and DU145 (A,B) and human breast cancer cell lines MDA-MB-231 and BT-549 (C,D) were transfected with SK1 (A,C) and SK2 (B,D) siRNA and Affymetrix Clariom S human array was performed as described in materials and methods. Gene ontology biological process and hallmarks of cancer gene sets were tested in gene set enrichment analysis using the clusterProfiler package, version 3.6. The t-statistic generated in the differential expression analyses was used as the metric, with all Entrez Genes as the background and a cut-off p-value of 0.05 after multiple testing using the false discovery rate.