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. 2019 Mar 27;10:303. doi: 10.3389/fphar.2019.00303

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Copyright © 2019 Alshaker, Wang, Brewer and Pchejetski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram of genes regulated by SK1/SK2 knockdown (KD) in prostate and breast cell lines. Human breast cancer cell lines MDA-MB-231 and BT-549 and prostate cancer cells lines PC-3 and DU145 were transfected with SK1 or SK2 siRNA and Affymetrix Clariom S human array was performed as described in materials and methods. Numbers of significantly regulated genes common to prostate or breast cell lines are shown in outer semicircles and the number of genes universally regulated by SK1 or SK2 KD in all cell lines is shown in the middle. These universal genes are listed below the circles.