Table 2.
Gene-set enrichment analysis of hallmark of cancer enrichment pathways in response to SK1 KD in prostate cancer cells.
| Description | Enrichment score | p-value |
|---|---|---|
| HALLMARK_UV_RESPONSE_UP | –0.402737052 | 0.0027 |
| HALLMARK_E2F_TARGETS | –0.382852104 | 0.0028 |
| HALLMARK_G2M_CHECKPOINT | 0.373919221 | 0.0028 |
| HALLMARK_P53_PATHWAY | –0.311816056 | 0.0028 |
| HALLMARK_XENOBIOTIC_METABOLISM | –0.31162798 | 0.0028 |
| HALLMARK_INTERFERON_GAMMA_ RESPONSE | –0.308977776 | 0.0028 |
| HALLMARK_FATTY_ACID_METABOLISM | –0.290319736 | 0.0134 |
| HALLMARK_ADIPOGENESIS | –0.290165971 | 0.0057 |
| HALLMARK_OXIDATIVE_ PHOSPHORYLATION | –0.273082408 | 0.0113 |
| HALLMARK_COMPLEMENT | 0.283316334 | 0.0246 |
| HALLMARK_HYPOXIA | 0.291083127 | 0.0185 |
| HALLMARK_IL2_STAT5_SIGNALING | 0.295293643 | 0.0154 |
| HALLMARK_TNFA_SIGNALING_VIA_ NFKB | 0.317881573 | 0.0077 |
| HALLMARK_MITOTIC_SPINDLE | 0.333397383 | 0.0046 |
| HALLMARK_KRAS_SIGNALING_UP | 0.367158279 | 0.0015 |
| HALLMARK_EPITHELIAL_ MESENCHYMAL_TRANSITION | 0.440097468 | 0.0015 |