Table 3.
Gene-set enrichment analysis of hallmark of cancer enrichment pathways in response to SK2 KD in breast cancer cells.
| Description | Enrichment score | p-value |
|---|---|---|
| HALLMARK_INTERFERON_GAMMA_ RESPONSE | –0.389698297 | 0.0043 |
| HALLMARK_ALLOGRAFT_REJECTION | –0.339536274 | 0.0043 |
| HALLMARK_KRAS_SIGNALING_DN | –0.28487173 | 0.0042 |
| HALLMARK_E2F_TARGETS | –0.278165758 | 0.0085 |
| HALLMARK_G2M_CHECKPOINT | –0.270306348 | 0.0129 |
| HALLMARK_GLYCOLYSIS | 0.317865223 | 0.0222 |
| HALLMARK_FATTY_ACID_METABOLISM | 0.326776858 | 0.0214 |
| HALLMARK_MITOTIC_SPINDLE | 0.348623881 | 0.0052 |
| HALLMARK_XENOBIOTIC_METABOLISM | 0.356201125 | 0.0013 |
| HALLMARK_HYPOXIA | 0.356508267 | 0.0013 |
| HALLMARK_APICAL_JUNCTION | 0.356988995 | 0.0013 |
| HALLMARK_EPITHELIAL_ MESENCHYMAL_TRANSITION | 0.373510215 | 0.0013 |
| HALLMARK_ADIPOGENESIS | 0.382867908 | 0.0013 |
| HALLMARK_HEME_METABOLISM | 0.390882683 | 0.0013 |
| HALLMARK_P53_PATHWAY | 0.424168593 | 0.0013 |
| HALLMARK_MYOGENESIS | 0.429404077 | 0.0013 |
| HALLMARK_UV_RESPONSE_DN | 0.445254468 | 0.0014 |