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. 2019 Mar 27;13:55. doi: 10.3389/fnbeh.2019.00055

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Copyright © 2019 Boyer, Jaouen, Ibrahim and Gascon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Locomotion is reduced in 9-month-old mice. (A) Total distance traveled in the PhenoTyper (20-h period, left panel) and in the open field (10-min period, right panel) was significantly decreased in 9-month-old mice (3 months, Phenotyper 76.48 ± 3.54 m, open field 3.43 ± 1.86 m; 9 months, PhenoTyper 58.84 ± 3.04 m, open field 2.77 ± 1.83 m). PhenoTyper *p = 0.0026, open field *p = 0.0219 (Kolmogorov-Smirnov test). (B) Time spent in close proximity to the walls of the open field was not modified in 3- vs. 9-month-old mice (3 months, 339.9 ± 14.82 s; 9 months, 327.35 ± 12.90 s).