Table 2.

KEGG pathways enriched among the PPI network formed by JIA loci target gene and their interactors (FDR < 0.05).

Pathway	Total	Expected	Hits	P-value	FDR	Empirical P-value
Neurotrophin signaling pathway	123	1.34	10	5.60E-07	1.21E-04	0.1
Cardiac muscle contraction	12	0.131	4	5.81E-06	6.30E-04	<0.01∗
Cell cycle	124	1.35	8	4.74E-05	3.43E-03	0.14
Hypertrophic cardiomyopathy	25	0.272	4	1.34E-04	7.25E-03	<0.01∗

Total = the total number of genes in each pathway; Expected = the expected number of genes in each pathway given the number of JIA target genes; Hits = the actual number of JIA target genes falling into each pathway; P-value = P-value of each pathway in enrichment test; FDR = false discovery rate of each pathway; ^∗empirical P-value < 0.01 based on permutation analysis.