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. 2019 Mar 27;10:236. doi: 10.3389/fphar.2019.00236

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Copyright © 2019 Zhou, He, Sun, Liu, Gao, Ren, Shu, Chen, Liu, Zhou, Deng, Xu, Li, Xu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between TRIB3 (251, A > G) genetic polymorphism and the hypotensive effects of the antihypertensives monotherapy in EH patients. Panels (A–C) respectively depicts that BP-changes from baseline in EH patients carrying the TRIB3 (251, A > G) AA and AG/GG genotypes after treatment with the drugs of CCBs, ARBs and ACEIs for 6 weeks. P-value were calculated by the linear mixed model and adjusted for baseline age, BMI, gender, SBP, DBP, total cholesterol, heart rate, triglyceride, HDL, LDL, FBG and other biochemical factors appropriately. Error bar indicated 95% confidence interval.