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Seven sirtuins in mammals.
| Sirtuin | Catalytic activity | Localization |
|---|---|---|
| SIRT1 | Deacetylase | Nucleus and cytoplasm |
| SIRT2 | Deacetylase | Cytoplasm and nucleus |
| SIRT3 | Deacetylase | Mitochondria |
| SIRT4 | ADP-ribosyl transferase | Mitochondria |
| SIRT5 | Deacetylase | Mitochondria |
| SIRT6 | Deacetylase and ADP-ribosyl transferase | Nucleus |
| SIRT7 | Deacetylase | Nucleus |
