Table 1.
Genetic associations with selenium levels and endometrial cancer risk.
| Instrumental variables | Chr:Pos* | R2† | EA | OA | EAFSe | Z-score | BetaSe | SESe | PSe | EAFEC | BetaEC | SEEC | PEC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs1789953 | chr21:44482936 | 0.04 | T | C | 0.14 | 5.52 | 0.16 | 0.03 | 3.4 × 10−8 | 0.13 | −0.04 | 0.02 | 0.12 |
| rs6586282 | chr21:44478497 | T | C | 0.17 | −5.89 | −0.16 | 0.03 | 3.96 × 10−9 | 0.17 | −0.04 | 0.02 | 0.04 | |
| rs6859667 | chr5:78745042 | 0.03 | T | C | 0.96 | −6.92 | −0.36 | 0.05 | 4.4 × 10−12 | 0.96 | 0.02 | 0.04 | 0.54 |
| rs921943 | chr5:78316476 | T | C | 0.29 | 13.14 | 0.29 | 0.02 | 1.9 × 10−39 | 0.29 | 0.00 | 0.02 | 0.90 |
*
from hg19;
†
pairwise LD in Europeans (1000 Genomes) provided for instrumental variables at the same locus;
Se, Selenium; EC, Endometrial cancer; EA, Effect allele; OA, Other allele; EAF, Effect allele frequency from each GWAS; Beta, effect size; SE, Standard error; P, P-value. BetaEC and SEEC are the natural log odds ratio of endometrial cancer risk and associated standard error, respectively. Estimates for Selenium levels have been taken from (13) and estimates for EC from (14).