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. 2019 Mar 27;9:182. doi: 10.3389/fonc.2019.00182

Table 1.

Genetic associations with selenium levels and endometrial cancer risk.

Instrumental variables Chr:Pos* R2† EA OA EAFSe Z-score BetaSe SESe PSe EAFEC BetaEC SEEC PEC
rs1789953 chr21:44482936 0.04 T C 0.14 5.52 0.16 0.03 3.4 × 10−8 0.13 −0.04 0.02 0.12
rs6586282 chr21:44478497 T C 0.17 −5.89 −0.16 0.03 3.96 × 10−9 0.17 −0.04 0.02 0.04
rs6859667 chr5:78745042 0.03 T C 0.96 −6.92 −0.36 0.05 4.4 × 10−12 0.96 0.02 0.04 0.54
rs921943 chr5:78316476 T C 0.29 13.14 0.29 0.02 1.9 × 10−39 0.29 0.00 0.02 0.90
*

from hg19;

†

pairwise LD in Europeans (1000 Genomes) provided for instrumental variables at the same locus;

Se, Selenium; EC, Endometrial cancer; EA, Effect allele; OA, Other allele; EAF, Effect allele frequency from each GWAS; Beta, effect size; SE, Standard error; P, P-value. BetaEC and SEEC are the natural log odds ratio of endometrial cancer risk and associated standard error, respectively. Estimates for Selenium levels have been taken from (13) and estimates for EC from (14).