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Varying degree of opioid receptor involvement in some pharmacological effect.
| Effects | MOP | DOP | KOP |
|---|---|---|---|
| Analgesia | +++ | ± | ++ |
| Sedation | ++ | – | ++ |
| Respiratory depression | +++ | ++ | – |
| Constipation | ++ | ++ | + |
| Euphoria | +++ | – | – |
| Dysphoria | – | – | +++ |
| Depressive behavior | – | – | +++ |
| Hallucination | ± | – | +++ |
| Physical dependence | +++ | – | + |
MOP, mu-opioid receptor; DOP, delta-opioid receptor; KOP, kappa-opioid receptor; ±, more or less; -, no effect; +, low effect; ++, intermediate effect; +++, high.
