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. 2019 Mar 27;10:572. doi: 10.3389/fimmu.2019.00572

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Copyright © 2019 Goldeck, Perry, Hayes, Johnson, Young, Roychoudhury, McLuskey, Moffat, Bakker, Kwakkenbos, Frossard, Rowland, Murtaugh and Graham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Outcome of sequential heterologous PRRSV challenge infection and kinetics of antibody responses. Six pigs were experimentally challenged by inoculation of PRRSV-1 Olot/91, SU1-Bel, 215-06, PRRSV-2 KS06-72109 (KS06), and PRRSV-1 Olot/91 at 35 day intervals. Protection against PRRSV challenges was assessed by measurement of rectal temperatures (A) and detection of PRRSV-1 (closed symbols) and PRRSV-2 (open symbols) RNA in serum samples (B). PRRSV N protein-specific (C) and PRRSV-1 Olot/91-neutralizing antibodies (D) were measured longitudinally in serum samples. PRRSV-neutralizing serum antibodies were assessed against heterologous PRRSV-1 and−2 strains. Phylogenetic relationships between the challenge strains and heterologous strains (indicated by ^*) were assessed based on ORF5 sequences (E) and neutralizing titers determined (F).