Table 2.
Effects of genetic or immunological manipulation of TL1A/DR3 expression.
| Model | TL1A Tx | TL1A-Tg | TL1A ko | DR3 ko | Anti-TL1A | References |
|---|---|---|---|---|---|---|
| Spontaneous phenotype | Ileitis, TH2 | (56, 57, 69) | ||||
| DSS | Worsening | Worsening | ⇓ Chronic | (36, 70) | ||
| TNBS | ⇓ Weight loss ⇓ Histology |
(57) | ||||
| SAMP ileitis | Protected | |||||
| Gai2 ko transfer | ⇓ Weight loss ⇓ Histology |
(36) | ||||
| Experimental allergic encephalomyelitis (EAE) | ⇓ Clinical score | ⇓ Clinical score | (43, 50) | |||
| Collagen-induced arthritis (CIA) | Worsening | Protected | (71) | |||
| Antigen-induced arthritis (AIA) | Worsening | ⇓ Chronic arthritis | Protected | (71) | ||
| Ovalbumin (Ova) lung hypersensitivity pneumonitis | Protected | Protected | (43, 62) |