Table 3.

Changes in GCF cytokines levels over time for the SRP + OT and SRP-alone groups.

		Baseline		1st month			3rd Month
		Mean ± SD	Between Groups P values a	Mean ± SD	Within Groups	Between Groups P values a	Mean ± SD	Within Groups	Between Groups P values a
GCF volume	SRP + OT (n = 18)	0.009 ± 0.008	N.S	0.006 ± 0.011	B vs 1st M 0.031*	N.S	0.005 ± 0.003	N.S	N.S
	SRP-alone (n = 18)	0.008 ± 0.004		0.005 ± 0.003	B vs 1st M 0.041*		0.005 ± 0.004	N.S
TNF-α(pg/μL)	SRP + OT (n = 18)	5.079 ± 4.04	N.S	1.553 ± 0.22	N.S	N.S	1.167 ± 0.22	N.S	N.S
	SRP-alone (n = 18)	5.868 ± 2.61		2.989 ± 0.70	0.038*		1.772 ± 0.43	N.S
IL-1β (pg/μL)	SRP + OT (n = 18)	15.808 ± 2.35	N.S	12.091 ± 1.88	N.S	N.S	11.041 ± 1.72	N.S	N.S
	SRP-alone (n = 18)	13.783 ± 2.02		12.625 ± 2.26	N.S		11.325 ± 1.66	N.S
IL-6 (pg/μL)	SRP + OT (n = 18)	6.088 ± 0.69	N.S	5.325 ± 0.71	N.S	N.S	2.083 ± 0.50	N.S	N.S
	SRP-alone (n = 18)	6.884 ± 0.88		5.351 ± 0.57	N.S		2.483 ± 0.45	1st vs 3rd M 0.046*
IL-8 (pg/μL)	SRP + OT (n = 18)	10.087 ± 0.75	N.S	9.333 ± 0.72	N.S	N.S	9.158 ± 0.74	N.S	N.S
	SRP-alone (n = 18)	12.383 ± 0.72		10.010 ± 0.74	B vs 1st M 0.013*		8.275 ± 0.71	N.S

*P < 0.05, Wilcoxon Sign Rank test.

SRP: Scaling and root planning, OT: Ozone therapy, TNF-α: Tumor necrosis factor-alpha, IL-1β: Interleukin-1beta, IL-6: Interleukin-6, IL-8: Interleukin-8.

SD: Standard deviation, N.S: Non significant, B: Baseline, M: Month.

^aComparison of GCF volume, TNF-α, IL-1β, IL-6 and IL-8 values between SRP + OT and SRP-alone groups by Wilcoxon Sign Rank test.