Figure 7.

Emotionality in GRM5^AA/AA mice. a, An examination of the average number of floats exhibited by male and female mice during a 15 min forced swim test revealed less floating behavior in GRM5^AA/AA (AA/AA) mice versus the other two genotypes. b, Likewise, GRM5^AA/AA mice spent more time interacting with a novel object during a 2 min test. c, Although females made fewer open arm entries than males when tested in the elevated plus maze, the number of open arm entries was gene dose-dependent. d, GRM5^AA/AA mice also spent more time in the open arm of an elevated plus maze than GRM5^TS/TS (TS/TS) and GRM5^TS/AA (TS/AA) mice. e, In contrast, an intra-BNST infusion of U0126 did not alter floating behavior in the forced swim test. f, Likewise, no effect of U0126 infusion was observed in the elevated plus maze. g, Cartoon depicting the locations of the microinjector tips within the BNST of mice treated with the different doses of U0126. Sample sizes are indicated in parentheses. *p < 0.05 versus TS/TS (t tests or LSD post hoc tests); **p < 0.05 versus TS/TS and TS/AA.