Table 5. Clinical characteristics and endoscopic findings according to combination antiretroviral therapy duration in the patients with good adherence.
≤6 M (N = 58) | >6 M ~ ≤5 Y (N = 60) | >5 Y ~ ≤10 Y (N = 55) | >10 Y (N = 27) | P-value | ||||
---|---|---|---|---|---|---|---|---|
Age, years, median (IQR) | 47.5 (39.8–55.5) | 53 (43.3–60) | 55 (50–62) | 59 (54–67) | <0.001 | |||
Male sex, No. (%) | 49 (84.5) | 53 (88.3) | 48 (87.3) | 23 (85.2) | 0.931 | |||
CD4 cell count/mm3, median (IQR) | 107.5 (36.5–296.0) | 457 (262.5–610.8) | 612 (464.5–793.3) | 595 (530–852) | <0.001 | |||
CD4 cell count <200/ mm3, No. (%) | 33 (56.9) | 7 (11.7) | 2 (3.6) | 0 (2.9) | <0.001 | |||
HIV RNA virus, log/mL, median (IQR) | 5 (2.8–5.5) | 0 (0–0) | 0 (0–0) | 0 (0–0) | <0.001 | |||
The median observation period, years (IQR) | 0.1 (0–0.3) | 3.0 (1.5–4.2) | 7.6 (5.2–18.8) | 12.0 (11.2–13.8) | <0.001 | |||
The median cART period, years (IQR) | 0 (0–0.1) | 2.5 (1.2–3.6) | 6.7 (5.1–9.7) | 11.5 (10.9–13.0) | <0.001 | |||
Endoscopic finding, No. (%) | ||||||||
Opportunistic infection | 16 (27.6) | 5 (8.3) | 0 (0.0) | 2 (7.4) | <0.001 | |||
Esophagus | ||||||||
Reflux esophagitis | 15 (25.9) | 16 (26.7) | 20 (36.4) | 4 (14.8) | 0.217 | |||
Esophageal candidiasis | 14 (24.1) | 5 (8.3) | 0 (0.0) | 2 (7.4) | <0.001 | |||
Esophageal ulcer | 8 (13.8) | 3 (5.0) | 1 (1.8) | 0 (0.0) | 0.035 | |||
CMV esophagitis | 4 (6.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.020 | |||
Stomach | ||||||||
Atrophic gastritis | 26 (44.8) | 32 (53.3) | 39 (70.9) | 22 (81.5) | 0.002 | |||
Erosive gastritis | 10 (17.2) | 13 (21.7) | 20 (36.4) | 10 (37.0) | 0.056 | |||
Erythematous gastritis | 22 (37.9) | 19 (31.7) | 13 (23.6) | 4 (14.8) | 0.119 | |||
Intestinal metaplasia | 11 (19.0) | 15 (25.0) | 19 (34.5) | 8 (29.6) | 0.293 | |||
Gastric ulcer | 8 (13.8) | 4 (6.7) | 7 (12.7) | 3 (11.1) | 0.619 | |||
Gastric cancer | 0 (0.0) | 1 (1.4) | 1 (1.7) | 1 (2.9) | 0.486 | |||
Kaposi sarcoma | 1 (1.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1.000 | |||
Duodenum | ||||||||
Duodenal ulcer | 1 (1.7) | 1 (1.7) | 1 (1.8) | 2 (7.4) | 0.467 | |||
Duodenitis | 7 (12.1) | 3 (5.0) | 3 (5.0) | 0 (0.0) | 0.202 |
M, month; Y, year; IQR, interquartile range; HIV, human immunodeficiency virus; cART, combination antiretroviral therapy; CMV, cytomegalovirus.