Table 1.
Characteristics of the included studies and their participants.
| Bacci et al.11 |
Bacci et al.12 |
Febbo et al.13 |
Gómez-Moreno et al.14 |
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|---|---|---|---|---|---|---|---|---|---|
| Case (n = 451) | Comparator (n = 449) | Case (n = 50) | Comparator (n = 109) | Case (n = 261) | Comparator (n = 439) | Case (n = 18) | Comparator (n = 39) | ||
| Mean age in years (range) | 63.5 (38–89) | 66.4 (35–92) | 56.2 (41–77) | NR | 70.2 | 65.2 | 64.4 (46–73) | NR | |
| Gender | Male | 246 | 202 | NR | NR | 170 | 234 | 12 | NR |
| Female | 205 | 247 | NR | NR | 91 | 205 | 6 | NR | |
| Procedure | Dental extractions | Dental implants | Dental extractions | Dental implants | |||||
| Total number of extractions | 926 | 894 | – | – | 629 | 1049 | – | – | |
| Single extraction | 477 | 452 | – | – | 146 | 281 | – | – | |
| Multiple extractions | 449 | 442 | – | – | 115 | 158 | – | – | |
| Type of oral anticoagulant | Warfarin | – | Warfarin | – | Warfarin | – | Rivaroxaban | – | |
| INR range | 1.8–4.0 | Normal INR | 1.80–2.98 | 0.98–1.21 | Mean INR: 2.68 | – | – | Normal PT value | |
| Local hemostatic strategy | - Oxidized cellulose - Absorbable sutures - Gauzes saturated with TA for 30–40 min - Ice pack on the cheek |
- Silk sutures - Compressive gauze soaked with TA for 30–60 min - Ice pack for 6–8 h post-operatively |
(only in case group) - Irrigation socket with a 4.8% solution of TA - Oxidized cellulose - Sutures - Bite gauze-soaked TA for 30 min - Administration of 4.8% of TA mouthwash 4 times per day for 2 days |
- Non-absorbable sutures - Compression with gauzes soaked in 5% TA for 30–60 min - Ice pack for 6–8 h post-operatively |
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| Number of participants with post-procedural bleeding | 7 | 4 | 2 | 3 | 9 | 0 | 1 | 2 | |
| Days after surgery that post-procedural bleeding occurred | 2–6 | 2 | 2 | 2 | 0–10 | 0 | 1 | 1 | |
| Country | Italy | Italy | Australia | Spain | |||||
| Study period | January 2006–December 2008 | NR | June 2010– June 2014 |
NR | |||||
| Study design | Prospective cohort study | Prospective cohort study | Retrospective cohort study | Prospective cohort study | |||||
| Newcastle–Ottawa scale scores | Selection: 3 Comparability: 2 Outcome: 3 |
Selection: 3 Comparability: 2 Outcome: 2 |
Selection: 2 Comparability: 2 Outcome: 1 |
Selection: 3 Comparability: 2 Outcome: 2 |
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Abbreviation NR, not reported; TA, Tranexamic acid, INR, international normalized ratio.