Figure 7.

miR-134-5p Inhibited the Media Degeneration, Dissection Formation, and Dilatation of Thoracic Aortas In Vivo

(A) Representative graphs of H&E staining for thoracic aortas from mouse models in control, Ad-vector, or Ad-miR-134-5p groups. Arrows indicated bigger, round VSMCs in TAD model. Data are means ± SD. Scale bar, 100 μm. (B) Quantitative analysis of media thickness of thoracic aortas from different groups. (C) Representative echocardiography images of thoracic aortas or abdominal aortas from aortic dissection models treated with PBS, Ad-vector, or Ad-miR-134-5p, n = 10/group. (D) Quantification for media lesion area of aortic dissection models in different groups. (E) Plot for aortic diameter of thoracic aortas or abdominal aortas from aortic dissection models in different groups. *p < 0.05; **p < 0.01; ns, non-significant.