Table 3.

Predicted pharmacokinetic properties of compounds 1, 3, 14, 15 and 16.

Compound	AlogP98	PSA-2D	Solubility level	Absorption level	BBB level	PPB	CYP2D6
1	3.647	68.259	2	0	2	True	True
3	4.532	47.443	2	0	1	True	True
14	3.664	59.328	2	0	1	True	True
15	3.208	59.328	2	0	2	True	True
16	4.945	50.796	2	0	1	True	False
G	4.267	47.443	2	0	1	True	True

AlogP98: Lipophilicity descriptor; PSA-2D: Polar surface area; AlogP98: Lipophilicity descriptor; PSA-2D: Polar surface area; Solubility Level: (0, Good; 1, Moderate; 2, Poor; 3, Very poor); Absorption Level: (0, Good; 1, Moderate; 2, Poor; 3, Very poor); BBB Level: (0, very high blood–brain barrier penetration; 1, high; 2, medium; 3, low).