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. 2019 Mar 20;2019:7973098. doi: 10.1155/2019/7973098

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Copyright © 2019 Huang Huang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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GSI or Atr abolished the protective effects of Api pretreatment on the maintenance of mitochondrial function after SI/R injury. (a) Flow cytometric histograms and column bar graph showing DCF fluorescence intensities. (b) The MMP levels evaluated by the ratio of fluorescence in the upper right quadrant and lower right quadrant. (c) The extent of mPTP opening evaluated as absorbance at 520 nm/min (ΔODmin⁻¹) changes (ΔOD = A520_0min − A520_30min). (d) Western blots showing cytosolic cytochrome c levels in cardiomyocytes. Values are presented as mean ± S.E.M. of 6 individual experiments. (a) p < 0.01 vs. control group; (b) p < 0.01 vs. SI/R group; (c) p < 0.01 vs. Api + SI/R group.