Table 1.
Association of RANK, RANKL, and OPG SNPs with AS susceptibility in Taiwanese.
| SNP | Risk allele frequency | Genotype frequency (%) | p trend ∗ | p FDR | Test for the mode of inheritance unadjusted | Test for the mode of inheritance adjusted for sex | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p | p FDR | OR (95% CI) | p | p FDR | OR (95% CI) | |||||||||
| RANK rs1805034 CT | C | CC | CT | TT | Additive | 0.0814 | 0.122 | 1.11 (0.99-1.25) | Additive | 0.0858 | 0.1287 | 1.11 (0.99-1.26) | ||
| Case | 745 (33.26%) | 121 (10.8%) | 503 (44.91%) | 496 (44.29%) | 0.0881 | 0.1322 | CC + CT vs TT | 0.0577 | 0.1387 | 1.16 (1-1.36) | CC + CT vs TT | 0.0651 | 0.0976 | 1.17 (0.99-1.37) |
| Control | 881 (30.96%) | 142 (9.98%) | 597 (41.95%) | 684 (48.07%) | CC vs CT + TT | 0.4963 | 0.5239 | 1.09 (0.85-1.41) | CC vs CT + TT | 0.4772 | 0.5727 | 1.1 (0.84-1.44) | ||
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| RANKL rs7984870 CG | G | CC | CG | GG | Additive | 0.0407 | 0.0922 | 1.12 (1.01-1.25) | Additive | 0.0517 | 0.1274 | 1.12 (1-1.26) | ||
| Case | 1203 (53.95%) | 235 (21.08%) | 557 (49.96%) | 323 (28.97%) | 0.0413 | 0.096 | GG + CG vs CC | 0.0694 | 0.1387 | 1.19 (0.99-1.44) | GG + CG vs CC | 0.0451 | 0.0976 | 1.22 (1.01-1.49) |
| Control | 1456 (51.05%) | 344 (24.12%) | 708 (49.65%) | 374 (26.23%) | GG vs CG + CC | 0.1244 | 0.2488 | 1.15 (0.96-1.37) | GG vs CG + CC | 0.2290 | 0.4616 | 1.12 (0.93-1.34) | ||
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| RANKL rs9525641 CT | T | CC | CT | TT | Additive | 0.0301 | 0.0922 | 1.13 (1.01-1.26) | Additive | 0.0487 | 0.1274 | 1.12 (1-1.26) | ||
| Case | 1204 (54.09%) | 235 (21.11%) | 552 (49.6%) | 326 (29.29%) | 0.0297 | 0.096 | TT + CT vs CC | 0.0651 | 0.1387 | 1.19 (0.99-1.44) | TT + CT vs CC | 0.0501 | 0.0976 | 1.22 (1-1.48) |
| Control | 1458 (51.01%) | 346 (24.21%) | 708 (49.55%) | 375 (26.24%) | TT vs CT + CC | 0.0881 | 0.2488 | 1.16 (0.98-1.39) | TT vs CT + CC | 0.1976 | 0.4616 | 1.13 (0.94-1.35) | ||
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| RANKL rs9533155 GC | C | GG | GC | CC | 0.048 | 0.096 | Additive | 0.0461 | 0.0922 | 1.12 (1-1.25) | Additive | 0.0637 | 0.1274 | 1.12 (0.99-1.25) |
| Case | 1241 (55.65%) | 219 (19.64%) | 551 (49.42%) | 345 (30.94%) | CC + GC vs GG | 0.1054 | 0.1581 | 1.17 (0.97-1.42) | CC + GC vs GG | 0.0613 | 0.0976 | 1.21 (0.99-1.48) | ||
| Control | 1508 (52.84%) | 318 (22.28%) | 710 (49.75%) | 399 (27.96%) | CC vs GC + GG | 0.1013 | 0.2488 | 1.15 (0.97-1.37) | CC vs GC + GG | 0.2308 | 0.4616 | 1.12 (0.93-1.33) | ||
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| OPG rs3102735 CT | C | CC | CT | TT | 0.5191 | 0.6229 | Additive | 0.5074 | 0.6089 | 1.05 (0.9-1.23) | Additive | 0.2826 | 0.3391 | 1.09 (0.93-1.29) |
| Case | 328 (14.72%) | 21 (1.89%) | 286 (25.67%) | 807 (72.44%) | CC + CT vs TT | 0.3413 | 0.393 | 1.09 (0.91-1.3) | CC + CT vs TT | 0.1699 | 0.2039 | 1.14 (0.95-1.37) | ||
| Control | 400 (14.06%) | 32 (2.25%) | 336 (23.63%) | 1054 (74.12%) | CC vs CT + TT | 0.5239 | 0.5239 | 0.83 (0.48-1.45) | CC vs CT + TT | 0.6071 | 0.6071 | 0.86 (0.48-1.53) | ||
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| OPG rs2073618 CG | C | CC | CG | GG | 0.7412 | 0.7412 | Additive | 0.7352 | 0.7352 | 1.02 (0.9-1.16) | Additive | 0.7789 | 0.7789 | 1.02 (0.89-1.17) |
| Case | 1705 (76.53%) | 659 (59.16%) | 387 (34.74%) | 68 (6.1%) | CC + CG vs GG | 0.3930 | 0.393 | 0.86 (0.62-1.21) | CC + CG vs GG | 0.3078 | 0.3078 | 0.83 (0.59-1.18) | ||
| Control | 2177 (76.12%) | 823 (57.55%) | 531 (37.13%) | 76 (5.31%) | CC vs CG + GG | 0.4161 | 0.5239 | 1.07 (0.91-1.25) | CC vs CG + GG | 0.4124 | 0.5727 | 1.07 (0.91-1.26) | ||
∗ p trend: the p value from the Cochran-Armitage trend test with 100000 permutations.