Table 4.
Association of RANKL SNP haplotypes with AS susceptibility in Taiwanese.
Haplotypes of rs7984870, rs9533155, and rs9525641 | Estimated frequency (%) | Permutation | Logistic regression | Logistic regression adjusted for sex | ||||
---|---|---|---|---|---|---|---|---|
AS (N = 1120) | Normal (N = 1435) | All (N = 2555) | p value∗ | p value | OR (95% CI) | p value | OR (95% CI) | |
G-C-T | 51.41% | 49.74% | 50.48% | 0.2412 | 0.2224 | 1.07 (0.96-1.2) | 0.2620 | 1.07 (0.95-1.2) |
C-G-C | 41.83% | 45.88% | 44.10% | 0.0034 | 0.0042 | 0.85 (0.76-0.95) | 0.0081 | 0.85 (0.76-0.96) |
Others | 6.76% | 4.38% | 5.42% | 3.33 × 10−4 | 1.57 (1.23-2) | 9.06 × 10−4 | 1.54 (1.19-2) |
∗The p value for the estimated haplotype was generated from 10000 permutations using the EM algorithm.