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. 2019 Mar 20;2019:8029863. doi: 10.1155/2019/8029863

Table 4.

Association of RANKL SNP haplotypes with AS susceptibility in Taiwanese.

Haplotypes of rs7984870, rs9533155, and rs9525641 Estimated frequency (%) Permutation Logistic regression Logistic regression adjusted for sex
AS (N = 1120) Normal (N = 1435) All (N = 2555) p value p value OR (95% CI) p value OR (95% CI)
G-C-T 51.41% 49.74% 50.48% 0.2412 0.2224 1.07 (0.96-1.2) 0.2620 1.07 (0.95-1.2)
C-G-C 41.83% 45.88% 44.10% 0.0034 0.0042 0.85 (0.76-0.95) 0.0081 0.85 (0.76-0.96)
Others 6.76% 4.38% 5.42% 3.33 × 10−4 1.57 (1.23-2) 9.06 × 10−4 1.54 (1.19-2)

The p value for the estimated haplotype was generated from 10000 permutations using the EM algorithm.