Table 4.

Association of RANKL SNP haplotypes with AS susceptibility in Taiwanese.

Haplotypes of rs7984870, rs9533155, and rs9525641	Estimated frequency (%)			Permutation	Logistic regression		Logistic regression adjusted for sex
	AS (N = 1120)	Normal (N = 1435)	All (N = 2555)	p value∗	p value	OR (95% CI)	p value	OR (95% CI)
G-C-T	51.41%	49.74%	50.48%	0.2412	0.2224	1.07 (0.96-1.2)	0.2620	1.07 (0.95-1.2)
C-G-C	41.83%	45.88%	44.10%	0.0034	0.0042	0.85 (0.76-0.95)	0.0081	0.85 (0.76-0.96)
Others	6.76%	4.38%	5.42%		3.33 × 10−4	1.57 (1.23-2)	9.06 × 10−4	1.54 (1.19-2)

^∗The p value for the estimated haplotype was generated from 10000 permutations using the EM algorithm.