Figure 1.

Dyslipidemia is associated with LNs hypertrophy. (A) Lymph node cellularity was determined in 6 and 24 weeks old WT and apoE^−/− mice and was expressed as fold change over WT mice. Data is pooled from four independent experiments with 4–5 mice per group in each experiment. (B) Immunoreactivity for B220 and TCRβ was examined in LN sections from WT and apoE^−/− mice at 22 to 28 weeks of age. (C) T and B cell numbers were examined by flow cytometry and results were expressed as fold change over WT mice. (D) The fold change in T and B cells over WT mice was examined. ***p < 0.0005.