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. 2019 Mar 27;10:575. doi: 10.3389/fimmu.2019.00575

Figure 5.

Figure 5

The extended lymphatic network in apoE−/− mice LNs exhibits structural abnormalities. (A) Immunoreactivity for LYVE-1 was examined in LN sections from WT and apoE−/− mice at 22–28 weeks of age. (B) Lumen area of cortical and medullary sinuses was determined on LN sections from 22–28 week-old WT and apoE−/− mice. n = 4 mice per group; ***p < 0.0005 (C) Immunoreactivity for LYVE-1 and B220, (D) LYVE-1 and collagen (Col) type IV or (E) LYVE-1 and CD31 was examined in LN sections from apoE−/− mice at 22–28 weeks of age. Images are representative of 3–4 independent experiments (n = 3–5 mice per group). Arrows indicate loss of LYVE-1 expression.