Figure 1.
Localization of the tested nonsynonymous (missense) amino acid substitutions in the structure of connexin 26. Note. The information about the structure Сx26 was obtained from the database of three-dimensional structures of proteins and nucleic acids PDB ID:2ZW3 (https://www.ncbi.nlm.nih.gov/Structure/pdb/2ZW3) [22]. Localization of the studied amino acids in structure of Cx26 was obtained using the 3D-structure viewer applet with the protein structure loaded software PolyPhen-2 (http://genetics.bwh.harvard.edu/pph2/). Detailed structure models of human Cx30 and Cx31 proteins are currently not defined.