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. 2019 Mar 13;4(1):42–50. doi: 10.1089/can.2018.0051

FIG. 3.

FIG. 3.

First row: Dimeric structural units of the rFAAH crystal structures 3QK5.pdb (green), 4DO3.pdb (orange), and 2VYA.pdb (cyan). Evidenced in each structure the hydrophobic intramembrane patches as white surfaces. Ball and stick are the cocrystallized inhibitor molecules, respectively, in 3QK5.pdb, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile; in 4DO3.pdb the NSAID caprofen and in 2VYA.pdb PF-450. From row 2 to 7, the BMs in the area near the hydrophobic intramembrane patches of the three crystal structures are drawn for the investigated six steroids (colors as in Fig. 1). BMs, binding modes.