Table 2.
Univariate and multivariate analysis for renal endpoint.
| 95% CI |
||||
|---|---|---|---|---|
| HR | Lower | Upper | p-Value | |
| Univariate analysis | ||||
| Baseline data at CsA commencement | ||||
| Age (years) | 1.035 | 0.994 | 1.078 | .092 |
| Gender (male vs. female) | 0.740 | 0.268 | 2.039 | .56 |
| Serum creatinine (per µmol/L) | 1.010 | 0.977 | 1.044 | .56 |
| eGFR (per ml/min/1.73 m2) | 0.996 | 0.975 | 1.017 | .69 |
| CKD stage (per stage) | 0.876 | 0.281 | 2.724 | .82 |
| Proteinuria (per g/d) | 0.984 | 0.854 | 1.133 | .82 |
| Serum albumin (per g/L) | 0.873 | 0.789 | 0.967 | .009 |
| Hypertension (yes vs. no) | 1.499 | 0.536 | 4.191 | .44 |
| Diabetes mellitus (yes vs. no) | 1.247 | 0.355 | 4.386 | .73 |
| Use of RAS inhibitors (yes vs. no) | 0.196 | 0.071 | 0.544 | .002 |
| Renal pathology | ||||
| Tubule/interstitial acute index (per) | 0.901 | 0.461 | 1.762 | .76 |
| Tubule/interstitial chronic index (per) | 0.975 | 0.525 | 1.812 | .94 |
| Artery/arteriole lesions (yes vs. no) | ||||
| Intimal sclerosis of small artery | 5.895 | 1.306 | 26.611 | .021 |
| Hyalinosis of arteriole | 1.838 | 0.664 | 5.090 | .24 |
| Data during follow up | ||||
| Occurrence of CsA-ARI (yes vs. no) | 2.171 | 0.744 | 6.330 | .16 |
| Occurrence of CsA-CRI (yes vs. no) | 1.902 | 0.657 | 5.509 | .24 |
| Complete/partial remission (yes vs. no) | 0.104 | 0.026 | 0.422 | .002 |
| Time average proteinuria (per g/d) | 1.775 | 1.414 | 2.229 | <.001 |
| Duration of cyclosporine use (per month) | 0.945 | 0.909 | 0.983 | .005 |
| Culmulative cyclosporine dose (per 100g) | 0.422 | 0.148 | 1.205 | .11 |
| Multivariate analysis | ||||
| Age (per year) | 1.031 | 0.975 | 1.090 | .28 |
| Gender (male vs. female) | 2.864 | 0.638 | 12.856 | .17 |
| Baseline serum albumin (per g/L) | 0.895 | 0.755 | 1.060 | .20 |
| Intimal sclerosis of small artery (yes vs. no) | 5.178 | 1.011 | 26.532 | .049 |
| Use of RAS inhibitors (yes vs. no) | 0.164 | 0.032 | 0.850 | .031 |
| Complete/partial remission (yes vs. no) | 0.581 | 0.028 | 12.145 | .73 |
| Time average proteinuria (per g/d) | 1.594 | 1.060 | 2.396 | .025 |
| Duration of cyclosporine use (per month) | 0.993 | 0.949 | 1.039 | .76 |
CsA: cyclosporine; eGFR: estimated glomerular filtration rate; CKD: chronic kidney disease; RAS: renin angiotensin aldosterone system; Non-CsA-RI: no cyclosporine related renal injury; CsA-ARI: cyclosporine related acute renal injury; CsA-CRI: cyclosporine related chronic renal injury.