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. 2019 Apr 3;365:l1161. doi: 10.1136/bmj.l1161

Table 2.

Number (percentage) of records in data extract stratified by year of birth, number of doses of bivalent human papillomavirus vaccine, cytological abnormality, referral for colposcopy, and histological diagnosis

Variables Year of birth Total
1988 1989 1990 1991 1992 1993 1994 1995 1996
No of records 17 589 16 801 17 471 17 618 16 669 16 050 15 854 15 229 5414 138 692
Vaccine doses:
 0 17 579 (99.9) 16 731 (99.6) 14 038 (80.4) 4994 (28.3) 3002 (20.3) 3283 (20.3) 2209 (13.9) 1665 (10.9) 545 (10.1) 64 026 (46.2)
 1 3 (0.02) 22 (0.1) 233 (1.4) 538 (3.1) 415 (2.5) 437 (2.7) 267 (1.7) 101 (0.7) 29 (0.5) 2051 (1.5)
 2 2 (0.01) 18 (0.1) 488 (2.8) 1196 (6.8) 815 (5.1) 833 (5.2) 548 (3.5) 161 (1.1) 38 (0.7) 4135 (3.0)
 3 5 (0.03) 30 (0.2) 2706 (15.5) 10 890 (61.8) 12 401 (74.4) 11 517 (71.8) 12 830 (80.9) 13 229 (87.3) 4802 (88.7) 68 480 (49.4)
Cytology result:
 Negative 14 500 (82.4) 13 923 (82.9) 14 302 (81.9) 14 780 (83.9) 14 031 (84.2) 13 640 (85.0) 13 452 (84.8) 13 080 (85.9) 4656 (86.0) 116 364 (83.9)
 Borderline/ASCUS 1819 (10.3) 1828 (10.9) 2102 (12.0) 1939 (11.0) 1624 (9.8) 1143 (7.1) 1112 (7.0) 1034 (6.8) 365 (6.7) 12 966 (9.3)
 Low grade dyskaryosis/LSIL 929 (5.3) 779 (4.6) 786 (4.5) 694 (3.9) 869 (5.2) 1111 (6.9) 1178 (7.4) 1061 (7.0) 375 (6.9) 7782 (5.6)
 HSIL-M 208 (1.2) 176 (1.0) 191 (1.1) 137 (0.8) 93 (0.6) 102 (0.6) 76 (0.5) 43 (0.3) 13 (0.2) 1040 (0.7)
 HSIL-S+ 132 (0.8) 95 (0.6) 90 (0.5) 68 (0.4) 52 (0.3) 54 (0.4) 36 (0.2) 8 (0.1) 5 (0.1) 540 (0.4)
Referral for colposcopy 680 (3.9) 612 (3.6) 557 (3.2) 434 (2.5) 355 (2.1) 295 (1.9) 278 (1.7) 120 (0.8) 20 (0.4) 3351 (2.4)
Histological diagnosis:
 CIN grade 1 122 (0.7) 102 (0.6) 98 (0.6) 76 (0.4) 63 (0.4) 60 (0.4) 45 (0.3) 26 (0.2) 4 (0.1) 596 (0.4)
 CIN grade 2 151 (0.9) 118 (0.7) 106 (0.6) 75 (0.4) 64 (0.4) 63 (0.4) 38 (0.2) 20 (0.1) 2 (0.04) 637 (0.5)
 CIN grade 3 or worse 103 (0.6) 81 (0.5) 86 (0.5) 66 (0.4) 53 (0.3) 38 (0.2) 29 (0.2) 9 (0.1) 4 (0.1) 469 (0.3)

ASCUS=atypical squamous cells of undetermined significance; LSIL=low grade squamous intraepithelial lesion; HSIL=high grade squamous intraepithelial lesion (HSIL-M=mild dyskaryosis; HSIL-S+=severe dyskaryosis); CIN=cervical intraepithelial neoplasia.