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. 2019 Mar 15;20(4):e46293. doi: 10.15252/embr.201846293

Figure 8. eCDNs promote cGAS‐mediated DNA sensing.

Figure 8

  • A, B
    qRT–PCR detection of Ifnb1 mRNA (A) or ELISA detection of IFNβ in supernatants (B) of mBMDMs infected with HSV‐1 at indicated MOI together with stimulation with ecGAMP at indicated concentrations for 4 h. Data are means + SD averaged from three independent experiments performed with technical triplicates. Each symbol represents the mean of technical triplicates. Two‐way ANOVA followed by Bonferroni's post hoc test was used for statistical analysis. *P < 0.05; **P < 0.01; ***P < 0.001.
  • C
    Western blot detection of indicated proteins in lysates of mBMDMs infected with HSV‐1 at indicated MOI together with stimulation with ecGAMP at indicated concentrations for 4 h. Data are representative of three independent experiments.

Source data are available online for this figure.