Liver LDU (Leishman‐Donovan units) at day (d) 28 in infected WT mice treated with anti‐IL‐10R antibody or isotype control antibody (left panel, n = 5 mice per group), or at d21 and d28 from WT (blue), IL‐10
+/− (open green circles) and IL‐10
−/− (filled green circles) mice (right panel n = 3–6 mice per group).
Day 28 splenic parasite burdens expressed as LDU with each data point representing an individual mouse in WT (blue) and miR‐132
−/− (miR‐132−/−; red) mice. Data from four independent infection experiments.
Mean WT and miR‐132
−/− spleen parasite burdens from the four independent experiments shown in (B). Lines link individual experiments.
Splenic parasite burdens relative to WT group (WT mean = 1) for each of the four experiments shown in (B), with each data point representing individual mouse.
Spleen size expressed as % body weight for d0 (naïve) or d28 L. donovani‐infected WT (blue) and miR‐132
−/− (miR‐132−/−; red) mice.
Liver size expressed as % body weight for d0 (naïve) or d28 L. donovani‐infected WT (blue) and miR‐132
−/− (red) mice.
Data information: Significance determined by unpaired
t‐test, and in (C) by paired
t‐test of mean values. *
P < 0.05, **
P < 0.01, ***
P < 0.001, ****
P < 0.0001.