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. 2019 Mar 4;20(4):e46620. doi: 10.15252/embr.201846620

Figure 5. miR‐132 promotes protective immunity to L. donovani .

Figure 5

  1. Liver LDU (Leishman‐Donovan units) at day (d) 28 in infected WT mice treated with anti‐IL‐10R antibody or isotype control antibody (left panel, n = 5 mice per group), or at d21 and d28 from WT (blue), IL‐10 +/− (open green circles) and IL‐10 −/− (filled green circles) mice (right panel n = 3–6 mice per group).
  2. Day 28 splenic parasite burdens expressed as LDU with each data point representing an individual mouse in WT (blue) and miR‐132 −/− (miR‐132−/−; red) mice. Data from four independent infection experiments.
  3. Mean WT and miR‐132 −/− spleen parasite burdens from the four independent experiments shown in (B). Lines link individual experiments.
  4. Splenic parasite burdens relative to WT group (WT mean = 1) for each of the four experiments shown in (B), with each data point representing individual mouse.
  5. Spleen size expressed as % body weight for d0 (naïve) or d28 L. donovani‐infected WT (blue) and miR‐132 −/− (miR‐132−/−; red) mice.
  6. Liver size expressed as % body weight for d0 (naïve) or d28 L. donovani‐infected WT (blue) and miR‐132 −/− (red) mice.
Data information: Significance determined by unpaired t‐test, and in (C) by paired t‐test of mean values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.