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. 2019 Feb 25;20(4):e46794. doi: 10.15252/embr.201846794

Figure EV3. The Switch I region of Rab8a is critical for its interaction with BAG6 (related to Fig 4).

Figure EV3

  1. Schematic representation of the Switch I region of the Rab8a‐Rab7a chimeric protein. The amino acid residues 33–45 (boxed region) of full‐length Rab8a were substituted with those of Rab7a and this mutant protein was designated as the “8a‐7a chimera”. The numbers denote the corresponding amino acids of human Rab8a and Rab7a.
  2. The 8a‐7a chimera protein with the T22N mutation showed greatly reduced affinity with BAG6 compared with the case in Rab8a (T22N).

Source data are available online for this figure.