FIG. 10.

Glibenclamide reduces hemorrhagic progression of contusion (HPC). (A-C) Images of coronal sections of brains through the epicenter, obtained in vehicle-treated animals 15 min after trauma (A) and 24 h after trauma (B), or in a glibenclamide-treated animal 24 h after trauma (C); the increase in area of brain exhibiting hemorrhagic transformation between 15 min and 24 h represents HPC. (D) Quantification of hemorrhagic lesion area (above) or hemispheric swelling (below) in vehicle-treated animals 15 min after trauma (black) and 24 h after trauma (red), or in glibenclamide-treated animals 24 h after trauma (green); 5 or 9 rats per group; box plot symbols same as in Figure 4; **p < 0.01 with respect to 15 min; ##p < 0.01 with respect to 24 h controls.