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. 2019 Mar 27;10:277. doi: 10.3389/fneur.2019.00277

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Copyright © 2019 Metcalf, Huntsman, Garcia, Kochanski, Chikinda, Watanabe, Underwood, Vanegas, Smith, White and Bulaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of music intervention in plantar incision model of surgical pain in CD-1 mice. (A)—Paw withdrawal latency (PWL; sec) following thermal stimulation in mice following plantar incision. Incised paws (ipsilateral) show a greatly diminished PWL as compared to non-incised (contralateral) paws. ^****P < 0.0001. (B)—Paw withdrawal threshold to mechanical stimulation following plantar incision. Thresholds in ipsilateral paws are shown as a percentage (%) of the contralateral paw withdrawal threshold. ^*P < 0.05. N = 13–15. Data were analyzed using a two-way ANOVA followed by a Bonferroni post-hoc test (A) or a t-test (B).