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. 2019 Apr;189(4):868–885. doi: 10.1016/j.ajpath.2018.12.010

Figure 12.

Figure 12

Analysis of embryonic tibia and 10-week–old knee joints in JNK1/2 dKO and control (CTRL) mice. A–C: Safranin O/fast green staining showing embryonic day (E) 17.5 tibia growth plate (GP) and mineralized regions (Min). D: Dot plots for comparisons of tibia GP and Min regions between E17.5 CTRL, heterozygous (Het), and dKO. E–G: Safranin O/fast green staining showing 10-week–old knee joint sections. H–J: Dot plots for comparisons of knee joint width (H), articular cartilage (AC) thickness (I), and tibial plateau [AC + GP + subchondral bone (SB)] thickness (J) between 10-week–old wild-type (WT), CTRL, and dKO. Data are expressed as means ± SEM (D and H–J). n = 4 (D, E17.5 CTRL, Het, and dKO; H–J, WT and dKO); n = 3 (H–J, CTRL). ∗P ≤ 0.05, ∗∗P < 0.01. Scale bar = 20 μm (A–C and E–G).