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Structural changes in non-diabetic db/+ compared to diabetic db/db kidneys. H&E staining of db/+ (A) and db/db (B) mouse kidney. Picro-sirius red staining of db/+ (C) and db/db (D) mouse kidney. Periodic acid–Schiff staining of db/+ (E) and db/db kidney tissue (F) with magnification of a representative distal tubuli lumen diameter of db/+ (G) and db/db (H) where lumen width is indicated. Quantification of glomerular circumference (I) and distal tubular lumen diameter (J).
