Fig. 4.

Tumor-bearing mice with CD11c-lineage-specific deletion of Dll1 exhibit increased Treg and decreased effector T-cell subsets. Lymphoid populations were evaluated by flow cytometry on day 17–18 after LLC tumor initiation in Dll1 knockout and wild-type littermate mice. Percentage of indicated populations are shown in CD4⁺ and CD8⁺ subsets in the tumor infiltrate (TIL) from knockout and wild-type littermates (a) with representative flow plots for CD4 versus CD25, and CD8 versus CD25 (b) and in a pool of splenocytes and LN cell cells from the same mice (c). Mean ± SEM, 5 mice per group, *, p < 0.05; **, p < 0.01