Fig. 6.

Gastrointestinal permeability of older adult mice to sugar probes. Gastrointestinal permeability was measured as altered ratios of sugar probes excreted in the urine. a B6 mice were treated with 5 mg aspirin two hours prior to feeding with sugar probes (open star sign, untreated n = 14; closed star sign, treated n = 6). b 10-week old or c 22-week old female B6 (closed diamond) or pIgR^−/− (open diamond) mice were given an oral dose of sugar probes containing sucrose, lactulose, sucralose and mannitol. The concentration of sugar probes in urine was collected 24-h post feeding and analysed by GC-MS. Data are represented as the ratio of sugar probe concentrations within samples and the horizontal bar represents the mean of each group. Statistical analysis was performed using the Mann Whitney U-test, ns indicates p > 0.05. Data are pooled from two independently performed experiments