Fig. 5.

VSG improves body composition but less than switch to standard chow. Six-week-old C57Bl/6j males and females were fed HFD for 12 weeks. At that time, animals underwent sham surgery or vertical sleeve gastrectomy (VSG). Sham animals were either switched to chow or remained on HFD for an additional 8 weeks. At 26 weeks of age, animals were sacrificed and a total weight, b GWAT weight, and c IWAT weight recorded. d GWAT H&E slides were imaged (e) and adipocyte sizing was performed. f Liver and g spleen weights were also recorded. *p < 0.05, ***p < 0.005, ****p < 0.001. #p < 0.05, significant differences are shown only between sham chow and VSG chow or sham HFD or VSG HFD N = 6–9 for VSG chow groups, N = 7–11 for adipocyte sizing, and N = 13–18 for all other data per group