Table 3.
Results of the meta-analysis of prognosis factors in SSc
| Number of cohorts | HR | 95% CI | I2 (%) | p(het) | Egger’s test | |
|---|---|---|---|---|---|---|
| Age at disease onset (per 1 year) | 6 | 1.05 | (1.04–1.07) | 68.6 | 0.007 | 0.783 |
| Age at diagnosis (per 1 year) | 5 | 1.04 | (1.04–1.05) | 71.2 | 0.008 | 0.025 |
| Male sex | 21 | 1.87 | (1.61–2.18) | 50.9 | 0.004 | < 0.001 |
| African origin | 5 | 1.38 | (1.15–1.66) | 25.0 | 0.255 | 0.774 |
| dcSSc | 23 | 1.90 | (1.62–2.23) | 58.3 | < 0.001 | < 0.001 |
| Anti-Scl70 autoantibodies | 13 | 1.38 | (1.09–1.74) | 49.6 | 0.022 | 0.024 |
| ACA | 8 | 0.62 | (0.47–0.82) | 56.4 | 0.025 | 0.590 |
| Joint involvement | 4 | 1.32 | (0.82–2.12) | 54.0 | 0.089 | 0.508 |
| Renal involvement | 9 | 2.79 | (1.95–3.99) | 50.9 | 0.039 | 0.512 |
| Scleroderma renal crisis | 10 | 3.89 | (2.38–6.36) | 75.6 | < 0.001 | 0.097 |
| ILD | 14 | 2.34 | (1.78–3.08) | 69.5 | < 0.001 | < 0.001 |
| Cardiac involvement | 7 | 4.35 | (2.28–8.29) | 89.9 | < 0.001 | 0.077 |
| PH (echocardiography or RHC) |
13 | 3.44 | (2.59–4.58) | 61.5 | 0.002 | 0.057 |
| PH (RHC) | 5 | 5.27 | (2.98–9.31) | 63.7 | 0.027 | 0.761 |
| Cancer | 6 | 2.11 | (1.27–3.50) | 76.2 | < 0.001 | 0.016 |
Results are expressed as hazard ratios with 95% confidence interval. The I2 statistics describes the percentage of variation across studies that is due to heterogeneity rather than chance. p(het) is the p value for the 휒2 test for heterogeneity. Egger’s test checks for funnel plot asymmetry
dcSSc diffuse cutaneous systemic sclerosis, ILD interstitial lung disease, ACA anti-centromere antibodies, PH pulmonary hypertension, RHC right heart catheterization