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. 2019 Apr 3;19:300. doi: 10.1186/s12885-019-5476-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Hypoxia regulates DNA repair genes at the transcript level. (a) Expression plots for multidrug resistance genes, abcb1, abcc1 and abcg1 in D283-MED cells incubated in 1% O₂ for 0–96 h. Filled circle and dark blue line show the average expression of the transcript. Open circle represents the data point for each individual probe. Numbers above data points show the fold change normalised to basal ratio. Shaded blue areas indicates the range of data variation. Expression profiles of genes involved in (b) non-homologous end joining or (c) homologous recombination for D283-MED cells incubated at 1% O₂ for 0–96 h. Green and red represent downregulation and upregulation respectively