Figure 3.

Caffeine does not affect cortical spreading depolarization-induced cortical blood flow changes. CBF response during the first or second CSD was not altered by caffeine, after acute administration (120 mg/kg) (n = 7) or chronic treatment (60 mg/kg/day for 2 weeks) (n = 5) when compared to vehicle (n = 7 and 5, respectively) (p > 0.05). The curves represent averaged CBF of individual animals at 5-s intervals, with time 0 indicating the inflection point at initial hypoperfusion. Vertical error bars show standard deviation of the amplitude of CBF change at inflection points. Horizontal error bars indicate standard deviation of time differences during CBF inflection points.