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. 2018 Apr 13;39(4):740–750. doi: 10.1177/0271678X18768955

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Figure 4. — Caffeine withdrawal does not affect cortical spreading depolarization threshold and frequency in R192Q mutant mice. (a) Representative tracings of the electrical threshold for CSD in R192Q mutant mice during caffeine withdrawal, compared to vehicle-treated R192Q mutant mice. “V” indicates electrical stimulation. Whisker box plots show that withdrawal of caffeine did not affect the genetically low electrical threshold for CSD in R192Q mice (p > 0.05). (b) Representative electrophysiological tracings of KCl-induced CSD frequency in R192Q mutant mice during caffeine withdrawal compared to vehicle-treated R192Q mutant mice. (c) Whisker box plots show that caffeine withdrawal (n = 7) did not affect CSD frequency when compared to vehicle (n = 5) in R192Q mutant mice (p > 0.05).